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In order to perform a fair comparison between the studies, we restricted the evaluation to only the genes that were commonly tested between each specific pair of studies.
Data Synthesis: Methodological design and quality varied considerably between the studies we reviewed.
Because of heterogeneity between the studies we have conducted stratified analyses for low CD4 cell count, HAART exposure and region.
To investigate heterogeneity between the studies we carried out metaregressions and subgroup analyses.
When the result of the Q test was statistically significant (p < 0.05), implying heterogeneity between the studies, we used random effects analyses, using the method of DerSimonian and Laird (1986).
Besides the methodological differences between the studies, we must take into account that this dysfunction could be caused by the direct action of STZ towards the myocytes as suggested elsewhere [ 40].
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Although HRQOL was different between centers participating in the study, we adjusted for this variable, thereby minimizing the potential for bias.
To understand the discrepancy between the two studies, we considered a number of differences between the Tee et al. experiments and our own.
As culture conditions, maturation methods and antigen sources differ between the conducted studies, we analyzed the functional differences between IL-4 MoDC and IFNα MoDC, loaded with blebs, in a head-to-head comparison using commonly used protocols.
If dispersal was included in the study we differentiated between "modeled" (m) and "specifically modeled" (sm).
Despite the difference in the kind of tissue and model between the two studies, we found many similarities in the biological processes.
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