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Genotype frequencies were generally in good agreement between the studies, although the study by Vannay et al. [18] showed a significantly different allele frequency at the rs2010963 SNP in controls from that observed in the other studies or from dbSNP data for subjects of European ancestry.
There is a significant overlap between the studies although it is clear that the slightly different treatments i.e. a sharp osmotic shock compared to the gradual loss of water have also resulted in the induction of some different response pathways and genes.
The blood pressure data should be interpreted with caution as blood pressure measurement techniques differed between the studies although similar conditions; non-fasting and resting prevailed in both places, The Oslo study used the automatic Dinamap method which is known to measure a lower diastolic blood pressure [ 31].
Similar(57)
For carcinomas, we observed the significant concordance of the regulation trends between the two studies, although the total RNA source and microarray platforms used for both experiments were not identical.
The I statistic (47.2%) indicated some heterogeneity between the six studies, although the effect size was similar with a fixed effect model (−0.28%, −0.36% to −0.19%) (−2.8, −3.6 to −1.9 mmol/mol).
Changes in case mix on the ICUs and implementation of other interventions (that is infection control measures) that influence the prevalence of antibiotic resistance could have occurred during the interval between the two studies, although based on reports of the participating hospitals we have no indication that either of these took place.
There were no significant differences in the total parasite count for the small intestine between the two studies although a trend of higher counts was seen in red deer in this study.
Data on ATRA and the 4-oxo metabolite are comparable between the two studies, although little detail is given in the phase I report (Khan et al, 1996).
For questionnaire items that were only moderately comparable, the nature of the observed relationships did not differ materially between the two studies, although many ORs differed significantly.
We found moderate heterogeneity between the studies (I=40.5%), although it was not significant (P=0.14; fig 3).
In addition to the small number of cases, the study did not account for the presence of psychiatric illness in the mother at the time of the study, although the association between psychiatric disorders and autism spectrum disorders is well known.
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