Among these toxins, only the ETD structure remained unknown, limiting our understanding of the structural determinants for the functional differentiation between these toxins.
Here, the search for the structural determinants of selectivity between selected serotonin receptor subtypes was carried out.
In other words, in a complex between a protein and a cognate ligand, the structural determinants of molecular recognition were subjected to natural selection.
We have not yet delineated the structural determinants of multiprotein-complex formation between Ras, RGS14, and Raf.
In previous papers, a set of eight 3-substituted-5,5-diphenylhydantoins [17] and a set of nine phenytoin-like anticonvulsant drugs [18] were assembled to analyze the structural determinants governing the partitioning of the solute between n-octanol and water.
However, from the comparison between the two osmotin/ADIPOR1 and ADIPOQ/ADIPOR1 complexes, it is evident that the structural determinants of these interactions are very similar.
This study (1) uncovers the structural determinants of FMDV thermolability, (2) investigates the relationship between virus thermolability and infectivity, and (3) provides a structure-based rationale for engineering thermostable virus particles to develop improved vaccines and nanocontainers.
Furthermore, we discuss the structural determinants that confer enzymatic specificity.
Arg219 is one of the structural determinants of the catalytic specificity of the alanine racemase.
The structural determinants governing the selectivity of GPCR/G protein coupling, however, remain obscure.
