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"You can ask the question, the research question, 'Is anything different between the stem cell from a sick person and a healthy person?'" says Jaenisch.
To validate the assay, Chapin's team tested over 90 compounds that had been studied previously in animals, and found nearly perfect agreement between the stem cell assay and real developmental toxicity results.
It was suggested that non-cell autonomous signaling between the stem cell pool and the OC is responsible for a homeostasis of SC number [4] [6].
However, a major hurdle to understanding and exploiting interactions between the stem cell and its environment is the lack of a tool for precise delivery of mechanical cues concomitant to observation of sub-cellular structural adaptation.
A major hurdle to understanding and exploiting interactions between the stem cell and its environment is the lack of a tool for precise delivery of mechanical cues concomitant to observing sub-cellular adaptation of structure.
This distinction between the stem cell and barrier theories therefore has important implications for interventions.
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In contrast, the global nucleosome occupancy was significantly different between all the stem cell lines and mouse embryonic fibroblasts (MEFs).
What we will be focusing on here is the relation between the stem cells lineages (their stemness) and the future development (fate) of the tissue.
Stemness relies on a very precise equilibrium between the stem cells and the components of the niche.
This close relationship between the stem cells and their niche has been shown by Rando and others to be vital in maintaining the function of stem cells.
They've also shown that this "death by dividing" is the result of a malfunction of the cross-talk that occurs between the stem cells, nestled along the lengths of muscle fibers, and their neighboring cellular support team known as the stem cell niche.
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