Sentence examples for between the seed sequence from inspiring English sources
Base-pair complementarity could be demonstrated between the seed sequence of a subset of human microRNAs and Alu repeats that are integrated parallel (sense) in mRNAs.
The nucleotide frequency difference between the seed sequence and the nucleotide variants in these three OTUs was much smaller than in the other 61 OTUs.
These small (∼21-mer) non-coding RNA molecules regulate gene expression by binding to 3' untranslated regions (3' UTR) of target mRNAs, triggering transcript degradation or translational repression depending on the extent of complementarity between the seed sequence of the miRNA and the mRNA motif [3].
The matching between the seed sequence (2 7 b.p). of the microRNA with the target mRNA sequence would suffice to initiate the regulation cascade by microRNA [ 38].
miRs are 20 25 nt small non-coding RNA molecules that control gene expression through base pairing between the seed sequence of the miR and its complementary match sequence on the target mRNA [11].
Ideal base pairing was observed between the seed sequence of mature miR-216b and 3′-UTR of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) mRNA; moreover, this seed sequence was highly conserved across species.
To highlight the relation between the seed sequences of miRNA families, we computed edit distances (Levenstein) between each pair of seed sequences of the differentially expressed families.
In addition, some researchers have considered wobble pairings between the seed sequences and 3′ UTRs in predicting target sites (Enright et al. 2003; Stark et al. 2003).
The novel finding of cross-kingdom similarities, in particular between the seed sequences of plant viral sequences, most of which are RNA viruses, and hsa-miRs, may provide an indication of the evolutionary conservation of this particular structural-functional feature of miRs.
Two subgroups were also identified: (1) those in which the seed sequence between nucleotides 2 7 were identical between plant virus and miR; and (2) those in which the seed sequences were identical and where the first nucleotide prior to the seed sequence was also a match.
The novel conserved miRNAs identified also showed 100% identity in the seed sequence between nucleotides 2 and 8.
