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Fisher's exact test was used to compare the proportions of unique variations between the response groups.
The mean number of unique variations per sample outside T-cell epitopes was compared between the response groups using a Poisson regression analysis.
Paired comparisons between the response groups found no significant differences in pre-chemotherapy mesothelin levels.
No relation between the response groups characteristics and the scores as defined by factor analyses of Q1 and Q2 was found to be relevant and significant.
The mean scores on the scale for the acceptability of priority care based on non-clinical factors differed significantly between the response groups.
A CART classification tree analysis of serum biomarker levels from these patients identified a three-biomarker panel consisting of α-fetoprotein, soluble vascular cell adhesion molecule 1, and MMP-9 that could distinguish between the response groups with 83% sensitivity and 91% specificity (Table 3).
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When it comes to good health, there are no statistically significant variations between the response group and the initial non-response group (table 3).
One-Way ANOVA with post-hoc tests showed that most differences between the six response groups on the three outcome items were significant.
On day 14, CEA kinetics could best distinguish between the two response groups (0% decrease in the progressive vs 22% decrease in the non-progressive group, P=0.037).
The miR-708 expresignificantlyicantly distributed in different patterns between the prednisone response groups.
Proxy responses will then be compared with those of the participants to assess the overall level of agreement and any systematic differences between the two response groups.
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