Sentence examples for between the reference genomes from inspiring English sources
We also found great differences between the reference genomes when they were used to diagnose the composition of the metagenomes.
Similarly, no clear difference between the reference genomes 'Prata Anã' (53; AAB) and 'BRS Platina' (84; AAAB) was detected.
Identification of orthologous introns between the reference genomes of each group: these introns are defined by their bracketing orthologous exons (shown in blue in Fig. 1 ).
Gaps between contigs were presumed to derive from plastome regions that are sufficiently divergent between the reference genomes and the sequenced species, such that no reads mapped to these regions, hence preventing inclusion in the de novo assembly.
Even with more stringent thresholds (e.g., coding divergence minus 1 SD or half of coding divergence) between the reference genomes and the most diverged species, although the differences become smaller, the patterns remain essentially the same (see supplementary fig. S2, Supplementary Material online).
Substitutions between human and chimp were inferred from the comparison between the reference genomes of the two species, using the syntenic net alignments between hg19 and panTro2 available on the University of California Santa Cruz (UCSC) platform (Karolchik et al. 2012).
The genomic sequence comparisons between the reference genome of E. anophelis NUHP1 and another ten available draft genomes of Elizabethkingia spp. (accession numbers: AVCQ00000000, AHHG00000000, ASAN00000000, ASYH01000000, ASYI01000000, ASYJ01000000, ASYK01000000, ASYF01000000, ASYG01000000, and ANIW01000000) were performed as follows.
Once the reads have been properly mapped, genomic variants can be discovered by identifying differences between the reference genome and the aligned reads.
We have developed MU2A, a variant assessment tool that accepts either genomic or transcript positions and reconciles the discordance between the reference genome and transcriptome when predicting the effects of sequence variants.
Differences between the reference genome and transcript libraries complicate the determination of the effect of genomic sequence variants on protein products; similarly, these differences complicate the mapping of sequence variants found in transcripts to their respective genomic position.
