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The relationship between the potential predictors and the breast density phenotype was examined using logistic regression.

The correlation coefficients between the potential predictors of the outcome measure pain ranged from.27 (i.e. pain (NRS) and depression (BDI)) to.52 (i.e. pain (NRS) and the impact of fibromyalgia (FIQ)).

In addition, the relationships between the potential predictors of the outcome measure depression ranged from.21 (i.e. beliefs in timeline (IPQ) and resting (PCI)) to -.31 (i.e. beliefs in personal control (IPQ) and resting (PCI)).

Finally, relationships between the potential predictors of the outcome measure global perceived effect ranged from -.20 (i.e. timeline beliefs (IPQ) and treatment control (IPQ)) to.62 (i.e. fatigue (FIQ) and impact of fibromyalgia (FIQ)).

The relationships between the potential predictors of the outcome measure interference of pain ranged from.18 (self-efficacy (DGSS) and beliefs in consequences (IPQ)) to.67 (i.e. psychological functioning (SCL 90) and anxiety (HADS)).

Abx appropriate antibiotic therapy, PRISM pediatric risk of mortality score, PELOD pediatric logistic organ dysfunction score, PICU pediatric ICU The association between the potential predictors and dichotomous outcomes of ventilator days >7, PICU LOS >7 days, and delta-PELOD > median are shown in Table  2.

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(DOCX 336 KB) 13717_2012_14_MOESM3_ESM.docx Additional file 3 Bivariate relationships between the potential predictor variables and change metrics.

Firstly, we investigated whether there was a linear relation between the potential predictor variables and the outcome.

Fourth, the sample size was inadequate to detect small, but clinically relevant, associations between the potential predictor variables and the DXA parameters.

Because the study is cross sectional in nature and many of the variables are time dependent, the temporal relations between several of the potential predictors and pattern of health-care use cannot be determined.

The univariate relationship between the outcome and the potential predictors were analyzed by Fisher's exact test or Wilcoxon rank-sum test as appropriate.

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