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In COS-1 cells, ERα and NFκB have also been found to have a synergistic action at the 5-HT1A recepromotermoter via NFκB sites, although this study also showed that E2 represses the activity of an NFκB response element in a synthetic construct, again suggesting that the interaction between the pathways is promoter specific (Wissink et al., 2001).
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The information about interactions between genes within the pathways is not used in our approaches.
Some of the identified dysfunctional crosstalk between the pathways are consistent with our knowledge for AD.
The dysfunction scores of the pathways and the interaction scores between the pathways are used for identifying the crosstalk.
Effectively targeting the DDR and DNA repair requires the thorough understanding of the interactions between the pathways being induced.
Further interconnections between the pathways are provided by the primary ET transcription factors ETHYLENE INSENSITIVE 3 (EIN3) and ETHYLENE INSENSITIVE 3-LIKE (EIL1) which repress SID2/ICS1 expression and thus decrease SA levels [ 73].
The correspondences between vertices in the pathways are given by matching the genes' official symbols.
Despite the differences, some of the pathways are conserved between chloroplasts and photosynthetic bacteria.
Still, many of the pathways were enriched between two or more metals.
Thus, the SLGIs within the pathways are rare and the SLGIs between pathways are significantly abundant.
This raises the question whether the cooperation between these pathways is restricted to the pancreas or whether similar mechanisms can also be found in other tumors.
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