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Instead, a procedure is provided to add cross terms between the parameter estimates and the plant states.
In the comparison of numerical results, good agreement between the parameter estimates was observed for datasets with up to three metabolites.
Results: The statistical power of meta-regression was dramatically and consistently lower than that of IPD analysis, with little agreement between the parameter estimates obtained from the two methods.
It is interesting to note that our construction does not require a linear parameterization, furthermore, viewed from a Lyapunov perspective, it provides a procedure to add cross terms between the parameter estimates and the plant states in the Lyapunov function.
However, as it is covered earlier, confounds between the parameter estimates, including the intraindividual differences, demonstrated the ability of the MLE with the non-Gaussian noise as a diagnostic tool for the COPD patients.
There were substantial differences between the parameter estimates.
Similar(46)
The correlation between the parameter estimate vectors of these runs was above 0.99.
Inter-subject variability in CL, Vc and Ktr (or Ka in the starting models) was estimated using an exponential error model as follows: 3where ηi is the proportional difference between the parameter estimate of the ith subject (Pi) and the typical population parameter value (TVP) and ηi is assumed to be normally distributed with a mean of 0 and a variance of ω.
NLME models allow "sharing" of information between individuals; hence, the parameter estimates derived in the current analysis are likely to be more informative.
Thus, the hierarchical method tunes itself to the degree of similarity between participants and adjusts the parameter estimates accordingly.
The between-subject effects and all of the parameter estimates of Fearless Dominance and Self-Centered Impulsivity were not statistically significant (all p > .46).46
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