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Synthetic lethality between the nuclear function of PAB3 and Gle2p suggests the inner face of the NPC as a possible site of PAB3 action in the nucleus.
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In a first step towards a better understanding of the relationship between the nuclear functions of the Whirlies and their primary localization to organelles, we decided to elucidate the functions of the Whirlies in mitochondria.
Experiment 1 When the nuclear function is the linear function, the experiment result is as shown in Fig. 3.
Experiment 4 When the nuclear function is the sigmoid kernel function, the experiment result is as shown in Fig. 6.
However, neither the mechanism underlying nuclear localization of γ-tubulin nor the nuclear functions of this protein have been elucidated.
A correlation between replication timing and transcriptional activity of proximal genes has been observed in many organisms, suggesting a connection between these nuclear functions.
(iii) How is the interplay between cPML and nuclear functions regulated?
Our data reveal the contact points of genome to the nuclear architecture and provide a link between nuclear functions and genomic packaging.
Co-ordinated nuclear function is predicated on the activity of distinct nuclear subdomains, or nuclear bodies, each responsible for a specific function.
Several essential cellular functions of mitochondria depend on a high degree of functional interaction between the nuclear and mitochondrial genomes.
OXPHOS is under dual genetic control, with communication between the nuclear and mitochondrial genomes essential for optimal assembly and function of the system.
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