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For the networks with no interconnections between the network modules (black) d2 is largest, as expected.
This means adding edges between the network modules helps in reducing the inference error.
The values of d2 decrease with an increasing number of interconnecting edges between the network modules.
These results correspond to the absence of a hierarchy between the network modules.
Similar(56)
The enrichment procedure determines whether there are significant overlaps between the input proteins and the network modules built for each GO BP term.
However, metabolic networks are far from perfectly modular no matter how the network modules are defined, there will be plenty of connections between them [4] [8].
After obtaining the network modules, we first checked which miRNAs may regulate the network modules.
Many adipose co-expression modules were enriched for genes differentially expressed between the two ethnicities or had differential connectivity (MDC) among members of the network module.
Network module 56 is the network module with the highest number of connections (53).
Thus, the overlaps between the predicted network modules and the coherent gene clusters from an independent study further indicates the importance of combining global and temporal gene expression datasets with physiological information such as gene functions and consensus sequences.
The lower genes connectivity correlation instead of gene expression intensity between N and PRE groups indicates that genes expression profile is similar in both situations (also partially supported by the similarities between network modules).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com