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Exact(8)
Namely, the distance between the native state and the transition state depends on the helix content linearly.
The osmophobic effect of glycerol, which preferentially raised the free energy of the activated complex, shifted the equilibrium between the native state and the activated complex in favor of the native state.
Because a distinct transition between the native state (N) and the intermediate state (I) is not observed during the urea induced denaturation of eIGPS-Δβ7α7-N231A (Figure 3B), kinetic unfolding experiments were performed to verify the existence of I and measure the free energy difference between N and I [6].
The slope of the force spectrum allows the determination of xu, which represents the distance between the native state and the transition state along the reaction coordinate.
This mutation has been shown to facilitate the transition between the native state and a conformation that is prone to the formation of ordered aggregates, termed polymers [ 7].
It can provide important information on local unfolding and the equilibrium between the native state oligomeric protein and its folding intermediates, since misfolded proteins are more susceptible to degradation by proteases (25).
Similar(52)
The Tetrahymena group I ribozyme partitions between folding to the native state and to a long-lived misfolded conformation.
In the case of lysozyme, hydrogen exchange experiments monitored using mass spectrometry have revealed the link between dynamics in the native state and amyloid fibril formation [82].
Small single-domain proteins often exhibit only a single free-energy barrier, or transition state, between the denatured and the native state.
We also find that the kinetic barrier between the intermediate and the native state is sufficiently low that the two species can readily interconvert.
More importantly, we determined the interconversion rates between these excited states and the native state.
More suggestions(15)
between the native genius
between the native conformation
between the native enzyme
between the native fluorophore
between the native experience
between the native ensemble
between the native structure
between the native population
between the same state
between the native film
between the native sequence
between the native silicon germanium
between the native fold
between the native vessel
between the native fox
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