Sentence examples for between the native ensemble from inspiring English sources
In the low-force regime, the unfolding rate is roughly force-independent due to the small (even negative) separation in X between the native ensemble and transition state ensemble (TSE).
While it appears that these models successfully model transition states and intermediates between the unfolded and native ensembles, it is unclear how accurately they capture smaller, yet biologically relevant, structural changes within the native ensemble after energetic perturbation.
Can a simple Gō-model of interleukin-1β, based on native topology, describe changes in structural properties of the native ensemble as the protein stability is changed?
We find that a low-level of frustration can actually stabilize the native ensemble and increase the associated diffusion coefficient.
The activity of the enzyme reflects the relative population of each conformation within the native ensemble.
Targeting the inactive state within the native ensemble may also provide additional probes for allosteric inhibition.
Similar experiments have revealed discrete conformational species within the native ensemble of signaling molecules, allosteric enzymes and membrane proteins [41,77,78].
The data further support the notion that the stability of helix 3 is important for maintaining the active state within the native ensemble.
In this way, the description of the native ensemble of the protein will be more or less complete depending on available experimental data.
Overall, the data show that the caspase-3 native ensemble includes the canonical active state as well as an inactive conformation characterized by an intact substrate-binding pocket, but with an altered helix 3. The enzyme activity reflects the relative population of each species in the native ensemble.
The results of modeling denatured protein in this manner reveal important sequence-dependent thermodynamic properties in the denatured ensembles as well as fundamental differences between the denatured and native ensembles in overall thermodynamic character.
