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No significant differences were found for stereotypies between the mouse genotypes.
We observed increased apoptosis in Grem1+/−; Apc Min /+ tumors (p = 0.044; n = 12; t test) and no other differences between the mouse genotypes.
Interestingly, G-CFU levels were not significantly different between the mouse genotypes, while a small, but significant decrease was found in the number of GM CFUs in the AnxA1−/− mice (Fig. 1 B).
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A critical and consistent difference between the two mouse genotypes is the earlier disruption of the BBB and the concomitant hemorrhagic lesions in H3R−/− mice at day 3 post-infection, a time when no clinical sign had manifested.
The delay in Hgf and Cyclin D1 expression also coincided with differences in the kinetics of ERK1/2 phosphorylation between the two mice genotypes, suggesting that growth factor stimulation required for hepatocyte progression up to G1/S boundary was also altered.
We next studied the radio-sensitivity difference between different mouse genotypes.
There was no difference in cardiac insulin receptor expression between mouse genotypes.
One could prioritize genes that are repeatedly differentially expressed between mouse genotypes that show similar phenotypic differences.
There was also no difference between serum cytokine levels of IL-1β, IL-6, IL-10 and IL-15 between the treatment groups and mouse genotypes (data not shown).
The NF-κB signaling pathway was found to be overrepresented in genes divergent between alcohol-preferring and nonpreferring mouse genotypes suggesting the participation of this system in establishing a high level of voluntary alcohol drinking [78].
Once the phenotype is known one can 1) group the mice from strains with similar genotypes and then 2) test for the phenotypic differences between the mice with the different genotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com