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Possible binding interactions between the most potent hybrid molecule A-1 and tubulin were also divulged by molecular modeling studies.
Therefore, the difference between the most potent and least potent ligands lies in the type of substituent and position of substitution on the pendant phenyl group.
The interaction between the most potent compound of the series and the c-myc G-quadruplex was examined in depth using UV Vis titration, molecular modeling and CD spectroscopy.
Key interactions between the most potent Compstatin analog that contains a noncanonical amino acid are presented and compared to the most potent analog containing only natural amino acids and native Compstatin.
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There's something about the space between us that creates the most potent ideas, so we always try to cultivate that space.
We performed epitope mapping studies of the binding between the enzyme and the most potent KdsD inhibitors found to date, together with studies of a set of newly synthesised arabinose 5-phosphate (A5P) mimetics.
Ligand-induced heterodimerization between erbB3 and erbB2, the most potent signaling complex amongst the various heterodimers, is one likely mechanism of Herceptin resistance [ 55].
Altogether, the elucidation of eight separate action spectra in rodents, monkeys, and humans showed that the short wavelength blue portion of the visible spectrum between 459 484 nm is the most potent wavelength region for a range of biological and behavioral responses in these species [for review, see Brainard and Hanifin (2005)].
The main difference between the MEPs of spipethiane, the most potent and least potent ligands is observed around the secondary hydrophobic site (Ar1 region) where there is an additional field generated around the substituent of the pendant phenyl ring of the least potent ligand.
"Between Two Worlds," one of the most potent pieces, dates from 1939 and reflects how keenly connected Kuniyoshi was to international events.
Despite the differing sequence preferences for stimulation between cell types and species, the most potent inhibitory sequences for all human and mouse cell types tested were as follows: TCCTGGAGGGGAAGT (2114); TCCTGGCGGGGAAGT (2088); TCCTGGATGGGAAGT (4024); and CCTGGATGGGAAGT (4084).
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