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There was no significant association between the molecular classification of CNC and the relative size of the necrotic zone (P > 0.05) (Table 2).
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Finally, the relationship between prognostic signatures and the molecular classification based on the coexpression modules was investigated by looking at the risk classifications on the plots of proliferation scores versus the molecular subtypes shown in Figure 4 (see Figure 4 of Additional data file 2 for analysis on all datasets).
The molecular classification described by Perou and colleagues showed, through the gene expression profile, remarkable differences between HR-positive tumors and HR-negative tumors [ 8].
Much of the current work in the molecular classification of tumors is actually discriminant analysis disguised as classification.
On top of the heatmap are labels for the molecular classification (index of Burkitt-likeness, molecular ABC/GCB-classification) and the presence of a chromosomal translocation of MYC.
In our analysis, no additional molecular markers were identified that further refine the molecular classification of diffuse gliomas.
We welcome the use of the molecular classification of breast cancer and gene-profiling assays.
In addition, the independent prognostic value of the molecular classification is currently unknown.
We next tested whether MEC populations influenced the molecular classification of the tumors they generate.
In addition, miRNAs appear to contribute to the molecular classification of tumors [ 4].
This could have therapeutic impact and could change the molecular classification of breast cancers.
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