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A study making a correlation between the light response property and morphology suggested that ON DSGCs in the mouse retina correspond to the Rgc1 type [41].
The enrichment of the GO categories "mitochondrial envelope" and "mitochondrial part" from the cellular component field (Figure S2 and Table S3) and of "mitochondrial diseases" in the MeSH analysis (Table S8) lends further support to a link between the light response and mitochondrial function.
We elucidated the function of an important node between the light response pathway and nutrient signaling.
To determine if PhLP1 and its regulatory targets GNB1 and GNG1 would function as a node between the light response pathway and nutrient signaling via the heterotrimeric G-protein cascade, we applied genome wide transcriptional analysis of Δ phlp1, Δ gnb1 and Δ gng1 in light and darkness.
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The change in outer segment volume is too small to account for differences between the light responses of StoA and TtoA rods and between WT and StoA rods, as now noted in the text (please see the subsection entitled "Response differences are not due to alterations in the transduction cascade").
The time to peak was defined as the time between the beginning of the light response and its maximum amplitude (i.e. the most negative value of the membrane potential); the response amplitude was the difference between the resting membrane potential and the membrane potential at the peak response; and the duration of the response was the duration of the hyperpolarization.
As there is a large on/off ratio between light on and off and the light response is centered at around 424 nm, the experimental results suggest that the PR-inserted ZnO/CuO CH can be used as a good narrow-band blue light detector.
With phlp1 emerging as a potential node between nutrient signalling and light response, we now analysed at which part of the light response pathway phlp1 might intervene.
For example, transcriptome analysis of the light response in leaf tissues from 3 japonica varieties (Nipponbare, TP309, and Kitaake) and an indica variety (IR64) revealed that about 10% of light-responsive rice genes differed between subspecies (Jung et al. 2008b).
On the other hand, the initial slope of the light response curve and the PSII yield suggested that the photochemistry is similar between the B and M segments.
We highlight the link between the pupillary light response and eye-movement preparation: When you intend to look at a bright stimulus, a pupillary constriction is prepared along with the eye movement before the eyes set in motion.
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