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Similarity was defined as the Pearson's correlation coefficient between the interaction profiles of the two genes.
These neighbor-based techniques exploit the similarity between the interaction profiles of different genes to predict missing values.
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We first prepared 10 drug molecules known to treat Alzheimer disease (AD) and 47 drug molecules chosen randomly from Drugbank [19] as the 'case' and 'control' drugs, hypothesizing that clear differences between the interaction profile of case and control drugs to multi-protein could be observed.
To produce the asymmetric course of the traveling waves revealed in our experiments, we incorporated an asymmetry in the interaction profiles between the layers of neurons that undergo mutual inhibition.
We assessed whether the observed difference in the strength and homogeneity of the interaction profiles between ES cells and embryonic brain cells was associated with distinct levels of background transcription.
We now report that such a transcriptional activation is implemented with little-if any-differences in the interaction profiles between the target genes and their neighboring gene deserts, unlike the situation observed during limb development where new contacts appear upon gene activation (Montavon et al., 2011; Andrey et al., 2013).
This interaction profile can then be used for determining both biological meaning and novel interactions for any pairs between the cluster nodes and the interaction profile nodes.
The shared interactome of four therapeutic antibiotics (ofloxacin, amoxicillin clavulanate, clarithromycin, and azizthromycin, allows for an inference of interaction between azithromycin and tuberculosis based upon the interaction profile of a cluster generated by hierarchically clustering a Pearson's correlation coefficient matrix.
Pearson correlation was used to measure both the interaction profile similarities and correlations between the distance profiles.
EMAP studies generally benefit from the following: (i) genome-scale study makes it possible to evaluate the extent of similarity between the genetic interaction profiles of two genes in an unbiased manner.
We constructed a correlation graph that represents the similarity between interaction profiles across all phenotypes for each gene pair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com