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Differences between the input function and system response are called transient errors during the transient period and are called steady-state errors during the steady-state period.
GLM analysis in this subgroup showed neither an effect of input function (F = 2.05, p = 0.186) nor a cross effect between the input function and region.
GLM analysis showed a significant effect of input function on BPND estimates (F = 16.94, p = 0.0005) and a cross effect between the input function and region (F = 2.69, p = 0.048).
GLM analysis in this subgroup confirmed a significant effect of input function on BPND (F = 96.46, p < 0.0001) and a cross effect between the input function and region (F = 4.88, p = 0.036), indicating that BPNDsuper differed from BPNDcerebellum across all ROIs in 56%% of our glioma patients.
GLM analysis revealed neither an effect of input function on BPND (F = 0.027, p = 0.874) nor any cross effects between the input function and region or side, indicating that BPNDsuper did not differ from BPNDcerebellum across all ROIs in the control subjects.
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In the current study, a linear relationship between the integrals of the input function and the whole blood concentration was used (i.e., the slope in Fig. 2).
There were no significant differences in the input function between the two groups (Fig. 1c).
A difficulty in this mapping is that the relationship between the whole blood concentration and the input function changes over time, and thus likely needs to be established for every radioligand separately.
Thus, a constant value for α indicates that, for t > t*, an equilibrium has occurred between the whole blood concentration and the input function (i.e., similar to what was assumed previously) [10, 21].
Models of both the input function and tracer movement between the blood vessel and the surrounding tissue can be simultaneously fitted to a total regional TAC taken from the vicinity of the blood vessel in the dynamic PET images.
The difference in the %COV between test and retest scans might come from errors included in the input function measurement.
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