In order to evaluate the similarity between the category and the individual functions, we computed the linear Pearson correlation coefficients as well as the above-defined distanceb between them and summarized the results in Table 5.
Based on results presented in this report, we propose the following models regarding the individual functions of, and interactions between, the members of LevQRST.
Two criteria were chosen to perform this analysis: (1) the Pearson correlation coefficient computed on the experimental data (usually reported in the literature) and the one computed between the predicted values of the individual models and of the proposed models for each category, and (2) an analytical distance between the individual integration functions and the categories' functions.
Third, we analyze the similarity between the individual integration functions and the models proposed category-wise.
The column Dmin/Dmax reports the smallest and the largest distances between the individual and the category functions associated with the category's index.
The column ρmax/ ρmin reports the highest and the lowest Pearson correlation coefficients between the individual and the category functions associated with the category's index.
(26 Cost saving CS {S m }) represents the difference between sum of the individual objective function and that of the objective function of coalition S m.
Although a compensatory up-regulation of PP1cα and PP1cβ isoforms was not particularly evident in PP1cγ−/− platelets, a potential redundancy between the individual PP1c isoforms in PP1cγ−/− platelet function is to be expected and may underlie the mild platelet phenotype seen in PP1cγ−/− mice.
We will focus on the differences between the functions of individual PCDH1 variants in future studies.
While this approach can not distinguish between the functions of individual AP-2 family members, it suggests that interfering with AP-2γ may sensitize to apoptosis even in the absence of functional AP-2α.
