These results suggested a correlation between the increased expression levels of miR-101, miR-30b, miR-30c, and miR-30d, as well as the decreased Sox9 expression level.
This supports the hypothesis that there is a correlation between the increased expression of defense-related genes and the enhanced resistance against pathogens in the ripening berry.
Clinical outcome association analysis revealed a strong correlation between the increased expression of the genes listed above and stage progression, favorable → unfavorable disease and alive → died-of-disease (data not shown).
There also was a positive correlation between the increased expression of IL-2 and that of its three receptor chains: IL-2Rα (r = 0.88), IL-2Rβ (r = 0.97) and IL-2Rγ (r = 0.85).
Probably, the effect of etoposide is the result of a balance between the increased expression of COX-2, linked to a major survival and migratory ability, and the reduced ICAM-1 expression, leading to a reduction of the metastatic potential of tumor cells.
Most of the genes that are differentially expressed between the models show increased expression in YAC128 striata and it is possible that this is due to the increased expression of HTT itself over the endogenous HTT expression.
The positive correlation between an increased expression level and H3K4me3 and AcH3 marks was even stronger among the top 200 most highly expressed genes (data not shown).
For the between breed contrasts, increased expression indicates higher in N'Dama compared to Boran and decreased expression indicates higher in Boran compared to N'Dama.
However, little is known about promoter hypomethylation of specific genes such as oncogenes and growth-related genes, with the exception of the association between demethylation and increased expression of c- abl, c- myc, Ha-ras, and raf (Cheah et al, 1984; Weitzman et al, 1989; Sharrad et al, 1992; Counts and Goodman, 1994).
