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The frequently observed hypermethylation of the RASSF1A promoter and downregulation of RASSF1A mRNA levels in parathyroid adenomas point toward an association between the inactivation of this tumour suppressor gene and parathyroid aberrant growth, whereas APC gene expression is retained in parathyroid adenomas due to increased transcription from APC promoter 1B.
The synergy between the inactivation of either PIF1 or ABF2 and the inactivation of NTG1 suggests that Pif1 and Abf2 are important for rho+ maintenance independently of the Ntg1-mediated pathway, underscoring the complexity of mtDNA transactions in yeast cells.
To investigate whether there was a link between the inactivation of MAPK/JNK signaling and the induction of organelle loss in the developing lens, MAPK/JNK activity was blocked in whole lens organ cultures using 2 distinct MAPK/JNK-specific inhibitors, SP600125 and JNK-IN-8.
To examine the link between the inactivation of the MAPK/JNK-MTOR signaling pathway and the induction of the autophagic process in the lens fiber cells, MAPK/JNK and MTOR signaling were blocked independently in lens organ cultures (E13) using SP600125 and rapamycin, respectively.
To resolve the lack of correlation between the inactivation of GSK-3β and the cellular β-catenin level after exposure to microcystin-LR, we considered the possibility that β-catenin might be degraded via the p53 siah-1 pathway after microcystin-LR treatment.
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Additional variability is observed between tissue types for the inactivation of some genes (7).
As mTORC2 is required for full PKB activation and PKB protects cells against rapamycin toxicity, we aimed to determine whether there was a causal link between the inhibition of mTORC2, the inactivation of PKB and the loss of islet viability.
Interestingly, methylation patterns on PAR regions (Fig. 7) appear to differ between male and Turner samples, and the inactivation of the second X chromosome in Klinefelter appears to be less effective than in females as could be inferred from the decreased methylation on the X-linked CpG sites (Fig. 6).
Crook and Eysel (1992) reported broadening of orientation tuning curves in 65% of neurons recorded in area 18 of the cat with the inactivation of local connections between columns of orthogonal orientation.
The inactivation of a virus is as much a culinary exercise as a chemical one.
Mentlein R. Dipeptidyl-peptidase IV (CD26 --role in the inaCD26 --rolef regulatory peptides.
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