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This test measures the association between the genotypes at the candidate locus QCK5e06 and the genotypic values for flowering time estimated for each individual.
The fact that ZEB1 expression increases dramatically in adipose tissue with fat accumulation (Figure 1B) complicates these experiments as there were no differences in ZEB1 levels between the genotypes at 4 or 5 months of age (data not shown).
These data confirm the high resemblance between the genotypes at transcript and protein levels.
Our first goal was to determine whether there was any association between the genotypes at four major maturity loci (E1 through E4) and photoperiod sensitivity.
There was no association between the genotypes at any of the four polymorphic sites in the Cox-2 gene and advanced adenomas in females.
Additionally there was no significant differences observed in the lesion lengths between the genotypes at 3 dpi and therefore this time point was selected to further investigate additional transcriptional changes that may elucidate other defence mechanisms.
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We investigated whether there was correlation between the genotype at the rs10088313 locus and the amount of NRG1 expressed in human gut tissues (40 patients and 21 controls) and found differences in expression as a function of genotype.
Significant associations were observed between the genotype at 372 in TAS1R1 and recognition thresholds for MSG (χ2 = 14.6, p = 0.0007) and M+I (χ2 = 6.19, p = 0.04), and between allele frequency at 757 in TAS1R3 and recognition threshold for IMP (χ2 = 6.19, p = 0.01).
Finally, they tested for association between the genotype at each locus and the abundance of each transcript enabling the generation of a comprehensive expression QTL (eQTL) database.
This investigation of the polymorphisms of HRH2, coding for the H2 receptor, reveals association between the genotype at the HRH2 -1018 G/A locus (rs2607474) and clinical response to clozapine treatment.
However, we did observe similar correlations between the genotype at rs1220 and the expression of miR-185a when comparing the Q-PCR and the microarray data (Table 1, Figure 6E and F).
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