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Despite the complex and important interplay between cytokine concentrations and platelets [[21]], we could not find any significant differences between the four study groups in measured cytokine concentrations on ICU admission.
Mean and standard deviations are shown for the key descriptive variables, including testing for differences between the four study populations, using one-way ANOVA.
Descriptive statistics (mean and SD) for each of the four studies are displayed in Table 2, all variables, except birth weight, were significantly different between the four study populations.
Approximately 40% of children enrolled in each group did not attend the last cross sectional survey but there was no difference in the response rate between the four study groups and this loss to follow up is unlikely to have biased our observation.
There were small differences in response rates between the four study groups.
No evidence was apparent for any heterogeneity in odds ratios between the four study centers.
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'Unclear risk of bias' was the common feature between the four studies.
The number of overlapped variants was 38,243, which was the largest number among the number of overlapping variants between the four study-specific reference panels and genotype panel of exome chip (Table 2).
Additionally we performed correlation analysis between the four studied cytokines.
There was no crossover between the two study arms.
P refers to the statistical significance of the difference between the two study drugs.
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