The fold decrease was largest between CD26+ G3 cancer cells and luminal cells, as possible from a cell-to-cell comparison.
The difference in fold decrease between G27 and the "−5 bp swap" was statistically significant with a p-value of 0.006, as was the difference between G27 and 26695 with a p-value of 0.0001.
The only commonality in expression patterns between the evolved strains was the >1.5-fold decrease in the transcript abundance compared to Founder of the following genes: fruBKA (fructose metabolism), sdaC (serine transport) and proK (proline tRNA).
Quantitation with primers that distinguish between the two isoforms demonstrated a two fold increase in the ey isoform concomitant with a two fold decrease the ey(2a) isoform (Fig. 3B, right panel).
The BTD level, which decreased 2.3 fold in the ICAT experiment, showed 1.96 fold decrease in the Western blot analysis.
The only significant difference between the two models is the eight-fold decrease in acute light induction of Y/GI in the PLD2loop model.
This may explain the two-fold decrease in the rate ratio associated with the current viral load between the univariate (marginal) and the multivariate (conditional) model.
We first determined the rate of elimination of the P3-CHA bacteriophage from the lungs of uninfected mice and found that its concentration decreased by slightly more than half-log/day (over 500 fold decrease between day 0 and day 4, Figure 6).
In order to compare the data between patients, the data are reorganised in Figure 1B according to the magnitude of the fold change: from highest fold increase to highest fold decrease in tumour compared with normal tissue.
