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These details need to be corrected and clarified throughout the manuscript so that the reader can make clear comparisons between the figures presented.
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It is very difficult to visualize the significant differences between these sub-states from the figures presented.
We thank the reviewers for pointing out the potential contradiction between the results presented Figures 7C and 8G. Figure 8G is a ligand affinity chromatography assay demonstrating that cyclopamine can indeed inhibit binding of the isolated Smo CRD-Fc to 20(S -OHC beadS -OHC
Most likely, the slight deviation between the figures in the present study and the OECD report is mainly due to the fact that, in my study, a subsample (with those who took both tests) of the full PISA sample is used.
The relationships between the covariates presented in Figures 1 and 2 and cord serum concentrations were evaluated by use of multivariate linear regression models (Tables 2 and 3).
Given the similarity between the results presented in Figure 7 and Ca2+ imaging studies [48], [55], [56] it may be possible to speculate that the Ca2+ channel sub-types are homogenously distributed over the apical dendrite of the L5 pyramidal neurons and the soma membrane.
Considering the disparity between the heat maps presented in Figure 1A and 1B, it is plausible that the exact same data processed in two different ways may yield two very different sets of candidate genes.
Although a major difference in the endpoint figures are seen between Blough et al.'s [ 4] data and Chung et al.'s [ 9] work, no difference exists between the data presented here and other figures.
This figure presents VAF pairs between co-clonal, sub-clonal, and different strand mtDNA substitutions.
Model of the relationship between variables is presented in Figure 3 and Figure 4 below: Figure 3 Relationship between variables in China sample.
The structure of the model, including the transitions between health states, is presented in Figures 1 and 2. Figure 1 presents the model structure for the IVIG treatment strategy.
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