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When our GLM demonstrated a significant overall statistical effect and a significant treatment group effect, we further explored pairwise comparisons between the exercise training groups vs. the control group using a Dunnett-Hsu post-hoc assessment.
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The low dosage employed could explain the lack of substantial difference in the reduction of IRLS score between the classical treatment and the exercise training.
Statistical analysis were performed using the statistical computer program SPSS 16.0 for Mac OS X. Differences between groups before and after the exercise training were statistically tested with an independent Student's t test.
Total energy expenditure during the exercise training sessions was matched between groups (1.30 ± 0.05 MJ per session).
The exercise training group performed tasks including resistance training, moderately intense exercise and training.
A repeated measures analysis of variance for intervention * time will performed to determine if there are any differences in effect between the two exercise training circuits.
To the best of our knowledge, this is the first time that the suggested connection between physical exercise training and the PGC1-α/irisin pathway is supported by the findings from a randomized clinical trial.
Therefore, additional and prospective studies are needed to uncover the mechanisms that explain the link between exercise training and autoimmunity.
Using such models with data from animal experiments would offer the opportunity to go beyond the simple quantification of the relationship between the amount of exercise training and performance and would thereby improve our knowledge about the nature of the adaptive processes that take place during training.
The vast majority of studies investigating the relationship between exercise training and cardiovascular health responses have applied running, cycling, or team sports participation as the training intervention [ 5– 7], whereas few have examined the effects of different aquatic exercise regimes [ 8– 10].
However, there was a significant interaction between the effect of exercise training and the presence of carotid plaques (p = 0.013), and significant reduced cIMT was demonstrated in the exercise group compared with controls in patients without identified carotid plaques (n = 65) [−0.034 mm (95 % CI −0.060 to 0.008) vs. 0.013 mm (95 % CI −0.011 to 0.038), p = 0.010].
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