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The average dS between perennial ryegrass and wheat genes were 0.32, with an average SD of 0.04 between the estimation methods.
However, the differences between the estimation methods are not as large based on the corresponding Top100Med values, which were either the same or differed by only one or two animals ranked in the top 100, with a maximum difference of 5 for HPLP-Quarterly.
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The other major difference between the models is the estimation method.
Only three data are needed to obtain the SDHFUPR: (1) the relationship between bladder volume and SDVOLUME for the estimation method that is used (determines the constants a and b), (2) the time points of image capture and (3) the estimated HFUPR.
This study suggests that the probability to detect inconsistency when present is between 14% and 21% depending on the estimation method.
Although we found no difference in the value of R for studies using confirmed cases versus unconfirmed cases in the estimation method, the trade-off between the accuracy of the less specific but more efficient and cost effective syndromic data compared to laboratory-confirmed influenza infections is unknown.
Therefore, we recommend to choose the estimation method with respect to the proposed area of application and to compare estimation results between different methods if they are not unique.
The estimation method is MLE.
The estimation method employed was maximum likelihood.
Conditional estimation with interaction was used as the estimation method throughout the NONMEM analysis.
To illustrate the differences between the four estimation methods from an established database, analyses were performed on data from the international CAPO dataset (see [ 3, 28] for details).
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