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Finally, we examined the correspondence between the enriched function of a biclique and the annotated functions of its domain.
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The enriched function, enrichment scores and P-values are given.
The higher the enrichment score, the more interesting the enriched function.
For kidney, the enriched function was 'positive regulation of steroid metabolic process' (P = 0.00057).
A hypergeometric distribution was used for each of the enriched functions to assess whether the TF-enriched functions were also enriched by differentially expressed genes during EMT.
Considering all above, we hypothesize that the enriched function-altering and pathogenic mutations in Tibetan highlanders may have played a role in adaptation of hypoxia environment.
The table shows the predicted activation or inhibition status of the enriched functions.
We used the following criteria to collapse the enriched functions to the most specific and the most enriched.
Additionally, we investigated the enriched functions of the crosstalk motifs.
A part of the enriched functions of lncRNAs have been validated by published studies [ 23- 26].
This process provided a higher level perspective of the enriched functions associated with these genes.
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