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There were also some baseline differences between the dosing groups in some B cell measurements.
While there were no statistically significant differences between the dosing groups, geometric mean titers following tetanus or pneumococcal vaccination were generally lower in subjects who were vaccinated 2 weeks after receiving abatacept, compared with control subjects.
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The study sample size was designed to be able to detect large differences in the frequency of adverse events between the dose groups.
As expected, the mean AUC and Cmax increased with increasing dose, although there was overlap between the dose groups.
No formal determination of sample size was performed and no formal statistical comparisons were made between the dose groups.
No clinically relevant difference in reduction of UI episodes was observed between the dose groups in either etiology.
The differences in mean baseline CSF Aβ levels observed between the dose groups were most likely due to chance resulting from the small sample size.
Liver and body weight, clinical chemistry, food consumption and Ki67 staining were analysed by 1-way analysis of variance to identify differences between the dose groups.
The range in gain in heightSDS was wide, and there were no significant differences between the dose groups; therefore, the results from the total study group were used for further analyses.
This approach does not account for multiple comparisons between each of the dose groups and the control group.
In addition to performing a trend test, scientists at the NTP are often interested in performing pairwise comparisons between each of the dose groups and the control group.
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