This behavior showed no significant difference between the dose-response groups.
A testable hypothesis requires a nontrivial difference in exposure between the groups being compared; the magnitude of difference that is nontrivial is a function of the dose response.
Milgrom et al. studied the dose response relationship between MS and xylitol chewing gums.
The dose response concurrent control included 99 participants out of the treatment group.
For this reason, only group differences in the descending limb of the dose-response curve (4 highest doses) were analyzed.
To compare the dose-response curves between treatment groups, one-way ANOVA with repeated measures were used.
11 Perhaps the differences in response between the two dose groups were related to this phenomenon, as at baseline the lower-dose group had more patients with very large spleens than the higher-dose group.
Although all subjects who received the F4/AS01 vaccine candidate seroconverted to the F4 antigen, no significant differences in antibody responses were seen between the 3 dose groups.
When performing ANOVA and linear regression, substantial lipolytic effects were seen in all groups as demonstrated by changes in the variables fat mass and leptin from baseline to 2 yrs of treatment; however, no dose response differences were observed between the GH dose groups for Δ fat massSDS, Δ leptin, Δ bone age, Δ BMD, Δ IVSd or Δ LVPWd (data not shown).
A clear dose response was apparent between the vaccination groups in terms of mucosal CD4 T cells, with the frequency of triple-positive cells (P = 0.02), IFN-γ and TNF-α dual-positive cells (P = 0.02), and IFN-γ only-producing cells (P = 0.02) significantly greater following vaccination via the aerosol route with a dose equivalent to a standard i.d.
18 19 20 21 22 23 24 25 26 27 Also, the consistent effects in the 250 mg dose group were not seen in the 50 mg dose group suggesting a dose response effect.
