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When a drug is used therapeutically, it is important to understand the margin of safety that exists between the dose needed for the desired effect and the dose that produces unwanted and possibly dangerous side effects.
Both in tumour models (Pan et al, 2002, 2003a, 2003b; Hassouneh et al, 2007) and in in vivo angiogenesis models, such as the Matrigel plug model (Juarez et al, 2006), ATN-224 has a strong antiangiogenic activity, and we wished to establish a relationship between the dose needed to inhibit angiogenesis and that needed to inhibit SOD activity in blood cells.
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The dose needed to cause an infection, however, is not known.
He also knew there was a significant relationship between the amount of alcohol consumed before treatment and the maximal dose needed by patients to obtain results.
The typical dose needed to ensure an optimal balance between effect and side effects is 30 50 mg daily.
But, he adds, the new research also raises further conundrums, from the radiation doses needed to damage the cardiovascular system to whether the effects differ between the sexes and whether the problem can be lessened.
Each dose costs $120, or $360 for the three doses needed for full protection, far more than any other commonly used vaccine.
There was no evidence of a correlation between patient weight and the daily maintenance doses needed to achieve a therapeutic level.
The dose of desmopressin needed to reach maximum concentrating capacity may vary between patients.
Intervals between chemotherapy doses are needed to allow repopulation of normal tissues.
And there was no difference between the two groups in the doses of drugs needed to control the disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com