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Moreover, theta rhythmicity showed different pattern of coherence between the distinct brain regions in response to social and fearful stimuli.
Moreover, social and fearful stimuli elicited different patterns of change in coherence between the distinct brain regions.
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Comparisons between these distinct brain regions showed that during early postnatal development, levels of spinophilin mRNA were not significantly different across all three brain regions, but with increasing age, levels of spinophilin mRNA were increasingly higher in the hippocampus relative to the cerebellum and cortex.
MVPA, compared to the univariate analysis, could detect subtle distributed effects and might consider the covariance between distinct brain areas as a signature of distributed brain networks.
Resting-state fMRI (rs-fMRI) has been widely used to explore the functional coupling between distinct brain regions by calculating low-frequency spontaneous fluctuations in the time series, i.e., functional connectivity (Biswal et al. 1995; Fox and Raichle 2007; Buckner et al. 2013; Song and Jiang 2012).
Whereas some studies have evaluated the functional relationship between distinct brain regions based on their time-synchronized activity, these studies do not allow for conclusions about the directionality of these interactions and their causal relationships.
Therefore, in particular functional MRI (fMRI), studies of the neural mechanisms of depression have shifted from those highlighting focal regions of abnormal brain functions to those focusing on the dysfunctional brain connectivity between spatially distinct brain regions.
To probe inter-regional coupling, we stimulated the subjects with 37 Hz amplitude-modulated (AM) tones and measured the distribution of the phase angle differences of the 37 Hz Steady-State Response between distinct brain regions.
The presence of a social stimulus thus appears to differentially affect the correlation of theta rhythmicity between distinct brain areas.
Psychophysiological interactions (PPI) analysis is another functional connectivity method used to analyze the coupling of neuronal activity between distinct brain regions while an individual is engaged in a task.
Our data indicate that the degree of sex-biased gene expression varies between distinct brain structures in adult mouse brain.
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