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Both in vivo and in vitro studies have demonstrated an inverse relationship between the differentiation of BMSCs into osteoblasts and adipocytes [43], [55], [56].
An inverse relationship between the differentiation of adipocytes and osteoblasts was demonstrated in cell and animal models and was found in various human diseases [12].
Indeed, inhibitor studies have demonstrated that Wnt and Activin (nodal) signalling is absolutely required for this process, indicating that fundamental parallels exist between the differentiation of early embryonic cell types in vitro and in vivo [16], [18] [20].
The correlation between the differentiation of symbiotic nodule cells and the first wave of nodule-specific gene activation suggests that the differentiation of the symbiotic cells constitutes a signal necessary for this transcriptome switch.
A correlation thus exists between the differentiation of symbiotic nodule cells and the first wave of nodule specific gene activation and between differentiation of rhizobia to bacteroids and the second transcriptome wave in nodules.
A positive correlation was observed between the differentiation of intracellular hyphae and the lignifications of the host-infected cell walls [ 23].
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Relationships between the significance of the differentiation of gene expression and connectivity degrees in the PPI network were established.
The distinction between in- and outparalogs allows the differentiation of recent from ancient paralogs.
We therefore looked for an association between the differentiation state of HCC and amounts of the PI4KA transcript.
There was no significant difference between the differentiation indices of the stabbed control and gel-treated groups.
Nevertheless, the study illustrates how imaging can be employed to understand the link between the differentiation state of cancer cells and invasive behavior.
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Justyna Jupowicz-Kozak
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