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This observation provides a link between the differential usage of the TrkB promoters and TrkB translation.
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To quantify the differential usage of a PAS between tissues, we computed the differences in the residuals.
This study demonstrates that the relationship is largely, or entirely, explained by the differential usage of DNA pol III subunit between aerobes and anaerobes: aerobes tend to carry the GC-enriching polymerase, and anaerobes the AT-enriching one.
Notably, the differential usage of codons represents the evolution of the 'demand' aspect of translation, namely the codon usage of all expressed genes.
In parasitoids, the differential usage of hosts may produce assortative mating as a pleiotropic consequence of female oviposition behavior.
Expectedly, there is a high correlation between differential usage and the "narrow" or "broad" status of a site.
As every cell type within one organism presumably contains the same genes, differential usage of the genome likely modulates functional differences between cell types.
The algebraic sign shows the direction of the imbalance of differential usage.
At the molecular level, differential usage of the two TrkB IRESes may be regulated in part by PTB1.
Two of these exons, named E1a and E1b, are highly conserved between mammalian species and their differential usage likely contributes to the tissue- and/or cell-specific expression of the GATA4 gene.
We conclude from these experiments that competition between Mg2+ and Ca2+ controls the net balance between AMPylation and deAMPylation and that this regulatory metal switch is implemented by differential usage of the inhibitory glutamate and the acidic residue in the FIC motif for binding metals.
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