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All mixture models consistently outperformed the classical model, but the comparisons between mixture models were less conclusive, giving small differences between the models and different ranking of the models between the different subsets (Table 7).
SAMseq showed the largest variability between the different subsets of the same size.
In the human data, differences between the packages were larger and so was also the variability between the different subsets, reflecting the inherently larger heterogeneity between the samples.
As there seem to be a strong correlation between the different subsets, regarding infiltration rate, a high amount of FOXP3+ cells can be an indication for an active and potent immune response, thereby explaining the association to better prognosis.
The proportion of conserved AT-ZFPs varies remarkably between the different subsets (Table 1), with minor proportions in sets A/B (6 of 33), C1 (2 of 77) and C2 (9 of 44), but a major proportion in set C3 (16 of 22).
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However, particle island methods do not rely on an exchange of particles between the PFs running the different subsets.
The regions for accepting the null hypothesis that "the differences in parameters between two different subsets of the same landslide dataset are derived from stochastic processes" are shown in Figs. 5 and 6 for γ and R, respectively.
As shown in Figure 7, no differences in the DNA methylation of RELB between the different CLL subsets were detectable, at least for this 5' region and the first exon.
The distribution of targeting antibody was similar between the different DC subsets regardless of the adjuvant used.
The inflammatory molecules and mediators involved in muscles affected by myositis are highly similar, given that some essential molecular paths engaged in immune response (innate and adaptive) are shared between the different IM subsets.
To study the relation between the different Treg subsets and survival, we determined the frequencies of the def.1, def.2, and def.3 Tregs in the PBMC of recurrent OvCa patients undergoing chemo-immunotherapeutic treatment (EM Dijkgraaf et al. submitted for publication) and correlated these levels to the overall survival (OS).
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Justyna Jupowicz-Kozak
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