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The interaction effect between the different sequence variants was evaluated and excluded from the analysis if not statistically significant.
(1) and (3) that the model is built on reproduction of individual sequences, but that mutations provide coupling between the different sequence types.
Sequence analyses of the 16S rRNA genes revealed nine sequence types of the Campylobacter strains and the similarities between the different sequence types were in the range 99.6 99.9%.
Maximum likelihood trees were generated using phyml v3.0 [ 60] with the most suitable model for each target region (1000 non-parametric bootstrapped data sets) to illustrate the genetic relationship between the different sequence samples and plotted in figtree v1.4.2 [ 61] (Additional file 5).
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Finally, no compound showed significant association rate differences (larger than error) between the different sequences examined in this study.
No difference in toxicity was observed between the different sequences and in both studies, myelotoxicity was dose limiting (Huisman et al, 2001; Mok et al, 2002).
This is also reflected in the sequence similarity between the different sequences in rice: OsEULD1A_1 and OsEULD1B_1 share the highest similarity to OsEULD2_1 (89 and 88% respectively) and the latter domain shares the highest similarity to OsEULD2_2 (90%).
We found inter-dependencies between the different sequences, and between the gene expression measures (Figure 2 and 3).
Before comparing sequence lengths and gene expression, we first determined if interdependencies existed between the different sequences themselves, and between the measures of transcript expression that we used.
The sequence coverage along the genome shows slight variations between the different sequencing platforms, likely arising from platform-specific biases (for an example, [30]).
In the absence of manual refinement, repeats may remain undetected if they are particularly divergent between the different sequences, and poorly aligned by automated methods.
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