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The relations between the different prediction uncertainties depend on both the data and the model.
To evaluate whether an improvement in prediction accuracy between the different prediction models is significant we compared the log10 pVL reduction at Week 8 for the patient samples classified to be in the at risk of X4 emergence group.
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Since all of these predictions are linked via the parameter distributions, the relations between the different predictions can be exploited for experimental design.
The model and data constrain the dynamics of the system and hereby implicitly impose non-trivial relations between the different predictions.
Many of them emphasize two of the most disturbing facts in the field, which are the lack of overlap between the different target prediction methods and the poor reliability found when predictions are validated using proteomics techniques.
However, even so, 14 of the 20 comparisons showed a significantly stronger than random correlation between the two different predictions (e.g. Figure 1A,B).
Among the common issues are low concordance between different prediction methods, high variance in performance across samples and the difficulties in constructing realistic and informative performance benchmarks.
The boundaries of putative TM helices or sheets tend to be predicted inaccurately and vary between different prediction methods.
It is assumed that the game server and clients (mobile devices) can switch between different prediction levels having different data rates.
The remaining 71 proteins were considered ambiguous in that they could not be assigned to any specific location due to a lack of consensus between different prediction programs (as described in Methods).
When differences of around 20 30% in Coiled-coil prediction were observed between the different methods utilized, the prediction was considered bad and not indicated in the list of Additional file 2.
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