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But at the same time, it is becoming clear that the molecular mechanisms resulting in familial AD pathology differ a lot between the different mutations [ 26].
We did not find any statistically significant difference in the sALP levels between the different mutations groups, which is not surprising since most of patients have already been treated for PDB.
Association between the different mutations was tested using Fisher's exact test.
Also consistent between the two methods is the relative strength of signal between the different mutations, with Myc most easily distinguished by both, and Ras the least distinguishable.
It is obvious that there are epistatic interactions between the different mutations associated with the emergence of drug resistance, the genetic environment, and compensatory mutations, but understanding these complex relationships will require further research.
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The ratios between the different mutation rates where chosen such that macromutations, which occur per genome, have a rate that is an order of magnitude larger than that of TFBS and gene mutations, which occur per TFBS or gene.
The HRMA was able to discriminate between the wt DNA and the different mutations present in the mutant cell line DNA.
HRM was able to discriminate between wild-type DNA and the different mutations present in the cell line DNAs using the 189 bp amplicon flanking exon 2. Figure 2 shows a normalised plot and a difference plot of the HRM data using wild-type DNA as a baseline.
To further evaluate the relationships between these different mutations, four additional viruses were constructed in which single and double substitutions at positions E2-60, E2-161 and E2-211 from the Ag41855 strain were substituted into the backbone of LR-GFP-226V (Table 4).
However, the studies published until recently did not differentiate between the different KRAS mutations and other histopathological or molecular features of their patients.
Noteworthy, the prominent role of novel mutations in contributing to HIV-1 drug resistance, the interaction between different mutations and the change of replication capacity of HIV-1 resistant strains remain unclear.
More suggestions(16)
between the different transformants
between the different mutants
between the different mutant
between the different factions
between the different studies
between the different ingredients
between the different properties
between the different species
between the different types
between the different CCUs
between the different sizes
between the different genes
between the spontaneous mutations
between the specific mutations
between the causal mutations
between the genetic mutations
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