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These data are used wherever available so as to avoid disparity between the databases.
This shows that identifiers that are ambiguous within these databases are relatively frequently shared between the databases.
Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers.
The implementation of this cutoff criteria led to a significant decrease in the resolution of the DFP to distinguish differences between the databases studied.
Table 3 presents for each pair of databases the number of unique non-systematic identifiers that are shared between the databases.
A Venn diagram showing the content overlap and differences between the databases or subsets that contain compound structures extracted from medicinal chemistry journals.
As shown in Figure 1, after excluding those overlapped between the databases, 217 abstracts were retrieved for detailed evaluation.
Hence, the linear correction is successfully reducing the bias introduced by the partial redundancy between the databases.
Cross comparisons of these three different ortholog resources showed significant differences in the protein sets, indicating low redundancy between the databases.
We are grateful to Frode Skjold for establishing functional connections between the databases and Magnus L. Persson for making the TMA blocks.
Figure 6 shows the cumulative precision and recall of the three individual databases and the integrated scoring after correcting for the dependency between the databases for both cases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com