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This is reflected in the average RMSD between the compared profiles shown in Figure 2B.
An important limitation of the above analysis is the potential variability between compared biological replicate datasets, as technical differences between the compared profiles may exist (e.g., sequencing depth differences; Peak caller deconvolution performance for broad patterns).
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For example with this time course data we could have used a similarity metric that incorporated a time lag between the compared expression profiles, however since the dataset used contained only eight time points we used non-time lagged statistic in order to achieve as stable a result as possible.
Cross-tabs were calculated to compare profiles between residents in small-scale living and regular psychogeriatric wards.
The expression profiles for all sets of targets were statistically analyzed in R using a two-sample Kolmogorov Smirnov test between groups, comparing the profiles of the subsets of targets as defined above to one another and against the expression profile of non-targets.
Lastly, in order to show up the likenesses and differences between strains, we compared their profiles of locus occupancy.
The first analysis compared expression profiles between NASH and S3 patients.
To obtain a global overview of gene expression in flower and fruit, we compared the profiles between three critical developmental time points.
Due to similarity of the toxicity effects between these two compounds, we compared transcriptome profiles between mercury and arsenic in the zebrafish liver using GSEA.
To discover genes that potentially contribute to virulence differences between strains, we compared the transcriptional profile of genes for the pathogenic phases of G186A and G217B.
This technique compares between the expression profiles of two samples, using hybridization of each sample to oligonucleotide-synthesized labelled probes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com