The interaction between ATF2-MK01 was identified only in the cellular function (0.6), but not in the molecular function, when the Gene Ontology Annotation Similarity Score was calculated.
These lacunas in the reconstructed LUCA gene sets may be interpreted in two ways: i) the missing genes actually emerged at a post-LUCA stage of evolution, which suggests radical differences in some of the cellular functions between LUCA and modern cells, and ii) these are cases of ancient non-orthologous gene displacement, with the "memory" of the ancestral state obliterated.
Numerous functional studies in human cells and yeast have established the physical and biochemical interactions between ATM and its targets, therefore the cellular functions and pathways ATM controls are well established [20].
The cellular functions remain hidden to us for the most part.
There is a complex, and still poorly defined, interplay between the multiple cellular functions regulated by the OPA1 protein.
We used PLS to map the levels of gene expression (X) to a metabolic function (Y), to gain an understanding of the interplay between a cellular function and the gene expression profile.
It represents the set of regression coefficients establishing the statistical relationship between fluxome state and the target cellular function, containing quantitative and qualitative information on the potential impact that each flux has on the target variable.
Considering the high levels of similarity between COPII paralogs and the basic cellular function that they perform, these findings suggest that COPII-dependent anterograde protein transport is a highly regulated process both during development and under physiological conditions in adulthood, and therefore is likely to be a factor in many more diseases than those already characterized.
However, molecular mechanisms underlying the relationship between ALS2-associated cellular function and its neuroprotective role remain unclear.
Defining cell types using a combination of markers is not always possible, and often the link between marker and cellular function is not understood.
