For example, it is unclear whether there is similar cellular composition between the cell types that could affect their responses to HRV16 and IL-13.
For example, when treating hMSC and 3T3-L1 cells with mesoporous silica nanoparticles of different surface charges, it was observed that uptake differed between the cell types [10].
Our results show how the initial rate of aggregation depends upon the cell seeding ratio, and how the distribution of cells within aggregates depends on the relative strengths of attraction and repulsion between the cell types.
Each of these processes could differ in efficiency between the cell types studied here.
We cannot, however, exclude the possible differences between the cell types.
Indeed, spike counts in four consecutive sections of the responses clearly demonstrate the differences between the cell types (see Fig. 4D).
It is unlikely that cardiomyocytes contributed to that HA synthesis, since cardiomyocytes alone did not synthesize HA at all, indicating a synergistic effect between the cell types.
Probably, this discrepancy could account for the differences between the cell types analyzed in our experiments and in the EST database.
The differences between the cell types, in proliferation and extent of differentiation, may be linked, in part, to the observed differences in ECM synthesis and methylation of imprinted genes.
Similar to the results of our analysis of the most common clusters in apical and basal cells, the functional categories showed a high degree of similarity between the cell types.
In this study we selected genes that discriminated between the cell types we had chosen to assay; this step improves the performance of the method but likely implicitly excludes the best markers for cell types that were not chosen.
