Your English writing platform
Discover LudwigSuggestions(5)
Exact(1)
We used one and two PEG spacers between the binding sequences to fine-tune biological properties of our homodimers.
Similar(59)
Binding of a TF to a gene regulatory region requires a match between the binding sequence of the TF and the operator region of that particular gene.
However this molecule showed low tumour uptake and substantial hepatobiliary clearance and the group focused on developing derivatives with a less-lipophilic benzonitrile one-step labelling moiety and inserting polar spacers between the labelling moiety and the binding sequence.
shRNA were used to demonstrate the function of Notch 1 in proliferation of mouse NSCs and luciferase reporter assay was used to assess and confirm the binding sequence of 3′-UTR between Notch 1 and miR-146.
At the resolution achieved chromosome-wide, we did not find a statistically significant correlation between the predicted binding sequences of the two alleles and recombination rates (Table S5).
We reasoned that if PRDM9 regulates the activity of a significant proportion of hotspots, it should be possible to find a correlation between the predicted binding sequences and recombination rates.
(C ) Relationship between the distance the remodeled nucleosome moved and the separation between the Gal4 binding sequence and the 601NPE.
Instead, the distribution peaked at the midpoint between the Gal4 binding sequence and the 601NPE.
(B ) Distributions of the locations of the nucleosome after ISW1a remodeling in the presence of Gal4DBD on three different templates of increasing separation between the Gal4 binding sequence and the 601NPE.
The coincidence levels between the binding site sequence and the sequence in the URR were fixed to optimise simultaneously the number of false positives and false negatives.
This amounts to requiring that the similarity between the sets of binding sequences of two TFs comparable to the similarity between the sequences of each TF.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com