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A mechanistic understanding of the link between the activating stimulus, local membrane environment, inactivation, and channel sensitivity may provide specific strategies for pharmacological modulation of Piezo activity.
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The nature of the activating stimulus dramatically influenced the cytokine made by B cells.
The contrasting observations in these papers could be due to differences in the activating stimuli (TNFα versus anti-CD3 and anti-CD28), differences between murine and human cells, or differences in responses between CD4+ and total T cells.
These proliferation sites are difficult to access and the activating stimuli difficult to recapitulate in vitro.
Again, spontaneous cytokine production could not be detected in the absence of an activating stimulus.
The canonical activating stimulus LPS was used as unconditioned stimulus (UCS).
Thus, although the wiring between the cell surface and Hippo is unclear, cell cell contact is likely to be an important activating stimulus (Zhao et al, 2007).
Our findings clearly demonstrate that the gene expression profiling of DCs reliably distinguishes between activating and non activating stimuli.
The NF-κB system transduces signals from a variety of cell-activating stimuli.
The strength-duration curve describes the relationship between the stimulus amplitude and its pulse width to activate a neuron (Lapicque 1907; Mogyoros et al. 1996; Irnich 2010).
When performed on the big cluster of voxels activated by all stimuli together, this comparison revealed no statistical differences between the two stimuli.
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