The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry.
Recently, a relationship between the abnormalities of DNA repair proteins and the oncoprotein Bcr-Abl was suggested (Deutsch et al, 2001).
Patients showed a graded relationship between the severity of the abnormality of the EEG background and the presence of obligatory and novelty ERP components for both sleep and wakefulness.
Similarly, there were no associations found between indoor air pollutants and the abnormality of FEV1%, except for CO (P = 0.003).
However, there was no association found between PM10, VOCs, and CO2 with the abnormality of FVC% among study respondents.
In contrast, in the specimens collected in September 2011, a high positive correlation between the abnormality rate of adults and the ground radiation dose was observed.
Several oncoproteins and oncogenic signalling pathways directly regulate vital components of the metabolic network, thus providing a link between the molecular abnormalities of cancer and the transformed metabolic phenotype (Deberardinis et al, 2008; Vander Heiden et al, 2009; Vousden and Ryan, 2009).
There was no statistically significant difference (P value of 0.22) between the abnormalities.
The effects of p53, and its abnormalities, on the response of tumours to cytotoxic drugs, radiation, and chemoradiation are complex (Blandino et al, 1999; Bunz et al, 1999; El-Deiry, 2003; Fei and El-Deiry, 2003; Gudkov and Komarova, 2003), and it is, perhaps, unrealistic to expect a straightforward relationship between any abnormality of p53 and the response to treatment with chemotherapy.
Because alterations in any component in the cell cycle regulatory p16/CCND1/RB1 pathway may have similar oncogenic effects, we studied the relationship between abnormalities of the CCND1 gene and altered expression of the RB1 gene, which had already been tested at the mRNA level (Bièche and Lidereau, 2000).
