Sentence examples for between telomere dysfunction and from inspiring English sources
Work done in yeast, plants and mice has demonstrated that loss of telomere function leads to genome destabilizing events, the study of which gives mechanistic insight into the relationship between telomere dysfunction and carcinogenesis [5], [20] [28].
Direct links between telomere dysfunction and the DNA repair pathways are starting to emerge.
No correlation between telomere dysfunction and p16 upregulation could be established (Supplementary Figure S1C).
In a more recent study, a link between telomere dysfunction and progerin accumulation was established during normal aging.
Second, we did not measure the ROS, which is key in evaluating cross-talk between telomere dysfunction and oxidative stress.
Further work on the possible link between telomere dysfunction and MK2 activity is clearly warranted in other systems.
We therefore examined the quantitative relationship between spontaneous telomere dysfunction and the in vitro proliferative life span of normal human cells.
Numerous studies indicate that, in the setting of WRN deficiency, dysfunctional telomeres trigger the onset of premature aging phenotypes, suggesting a link between increased telomere dysfunction and the genomic instability associated with the aging process (d'Adda di Fagagna et al 2003; Takai et al 2003; Smogorzewska and de Lange 2004; Chang et al 2004; Du et al 2004).
Extensive loss of telomeric DNA and proteins induce telomere dysfunction and activation of numerous DDR proteins at the telomeres including phosphorylated histone H2AX (γH2AX), resulting in telomere dysfunction-induced foci (TIFs) [2], [3].
In the absence of high telomerase activity, shRNA-mediated knockdown of hStn1 resulted in aberrant and fragile telomeric structures, stochastic telomere attrition, increased telomere erosion rates, telomere dysfunction, and consequently accelerated entry into cellular senescence.
We summarize data showing that perturbation of their telomere activities can lead to telomere dysfunction and genome instability and in some cases human disease.
