The mean fluorescence intensities between subtype 2 of different groups did not change dramatically, except a significant difference between the 1 g control group and the incubator control group.
Regarding the differentiation between subtypes of the same grade, FA was significantly different between subtypes of benign meningiomas [ 80], whereas ADC and rCBV did not contribute either in benign or malignant subtype discrimination [ 80, 81].
Among the different subtypes of OEC, different expression pattern was observed between early and late types.
In agreement with this, ER-positive and ER-negative patients have previously been shown to have differential miRNA expression signatures [ 2], and differential expression of miRNAs between tumors of different subtype and grade has also been reported [ 2, 17, 35].
Our results demonstrate a clear variation in the prevalence of CD44+/CD24- tumor cells between breast tumors of different subtypes.
In most of these studies, however, the expression of Snail and Slug has not been evaluated and compared between different subtypes of ovarian cancer which are now considered as different disease entities with distinct biomarker expression profiles [ 8, 9].
Comparisons of BCVA between groups of different lesion subtypes were conducted using Kruskal-Wallis test.
Genetic reassortment between segments of different virus subtypes during co-infection of a host cell further contributes to progeny diversity, providing a basis for rapid evolution and emergence of new avian influenza viruses in the wild (7 ).
Of these, three have identified hypermethylation in the promoter of tumor suppressor genes [ 6- 8] while two others have identified unique methylation patterns that can help distinguish between tumors of different histologic subtypes [ 5, 9].
Nonetheless, we have demonstrated that CARS imaging is reliable, sensitive and specific in discriminating between different subtypes of breast cancer, e.g., non-invasive in situ vs. invasive, different histological subtypes, e.g., DCIS vs. IG-IDC & ILC, and different histological grades of carcinoma, e.g., intermediate vs. high grade.
