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Only primary studies investigating variations in diagnostic test performances between subgroups were considered.
A Poisson distribution was assumed in the calculation of the 95% CI and differences in incidence rates between subgroups were considered significant if the CIs did not overlap.
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We also stratified these LNN patients into ER-positive and ER-negative subgroups as these subgroups are considered biologically distinct.
A treated subgroup was considered to have weaker expression than another treated subgroup if, among the genes that were differentially expressed between these two subgroups, it had more lower-expressed genes than higher-expressed genes.
Safety and subgroup analyses were considered secondary.
Two way interactions between variables were considered.
No differences between subgroups were identified.
No large differences between subgroups were observed.
Furthermore, variations between subgroups were observed.
Subgroups with a 5-year survival higher than 90% were considered as good prognosis, between 65 and 89% as intermediate prognosis, and lower than 65% as poor prognosis.
These samples were considered as a tumor subgroup in further analysis.
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